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Bloquea un mecanismo protector de las células cancerosas y permite que el sistema inmunitario las destruya. El anticuerpo monoclonal contra la proteína de muerte celular programada 1 (PD-1) bloquea la interacción entre PD-1 y sus ligandos: PD-L1 y PD-L2.</p><p> Los precios de Keytruda se especifican en este listado. Envíe una solicitud para obtener un presupuesto personalizado. </p></div><h2> ¿El pembrolizumab está aprobado por la FDA?</h2><i class=\"fa fa-angle-down\"></i><div class=\"accordion-item-text\"><p> El 23 de mayo de 2017, la Administración de Drogas y Alimentos de EE. UU. otorgó una aprobación acelerada a pembrolizumab (Keytruda), una aprobación más rápida de medicamentos para afecciones graves que satisfacen una necesidad médica no cubierta. La FDA permitió recetar un nuevo fármaco de inmunoterapia para tratar a pacientes cuyos cánceres tienen una característica genética específica (biomarcador). </p></div><h2> <strong>¿Cuáles son las tasas de éxito de Keytruda?</strong></h2><i class=\"fa fa-angle-down\"></i><div class=\"accordion-item-text\"><p> Durante los ensayos clínicos de Keytruda, se lograron los siguientes indicadores:</p><table><tbody class=\"block-green-frame\" style=\"width:100%;\"><tr><td><p> <strong>Período</strong></p></td><td style=\"text-align:center;\"><p style=\"text-align:center;\"> <strong>La tasa de supervivencia de pacientes con 3-4 etapas de cáncer</strong></p></td></tr><tr><td><p> 6 meses</p></td><td><p> 92%</p></td></tr><tr><td><p> 1 año</p></td><td><p> 69%</p></td></tr><tr><td><p> 1,5 años</p></td><td><p> 62%</p></td></tr><tr><td><p> 2 años</p></td><td><p> 58% </p></td></tr></tbody></table></div><h2> ¿Quién produce Keytruda?</h2><i class=\"fa fa-angle-down\"></i><div class=\"accordion-item-text\"><p> El fabricante es Merck &amp; Co., Inc., una compañía farmacéutica estadounidense y una de las compañías farmacéuticas más grandes del mundo. La investigación realizada en Merck ha conducido a la aprobación por parte de la FDA de 63 nuevos medicamentos. La compañía ha desarrollado más medicamentos nuevos que cualquier otra compañía en los EE. UU.</p></div>"},"guide_mc":{"text":"<p>Día 1</p><ul><li> Llegada al país y registro en el alojamiento.</li><li> Prepárese para las pruebas médicas iniciales al día siguiente.</li></ul><p> Dia 2</p><ul><li> Sométete a un hemograma completo con marcadores de cáncer.</li><li> Realice un proteinograma para evaluar sus niveles de proteína.</li></ul><p> Día 3</p><ul><li> Consulta con el oncólogo para analizar los resultados de las pruebas.</li><li> Plan y cronograma de Inmunoterapia con Keytruda (Pembolizumab).</li></ul><p> Día 4-5</p><ul><li> Iniciar Inmunoterapia con Keytruda (Pembolizumab).</li><li> La sesión dura entre 30 minutos y 4 horas.</li><li> No se requiere anestesia para este tratamiento.</li></ul><p> día 6</p><ul><li> Consulta postratamiento con oncólogo.</li><li> Discusión sobre los efectos secundarios y precauciones.</li></ul><p> Día 7</p><ul><li> Descansa y recupérate en tu alojamiento.</li><li> Prepárate para el viaje de regreso a casa.</li></ul><p> Semanas 2-4</p><ul><li> Controle cualquier efecto secundario o reacción.</li><li> Comuníquese con la clínica si surge alguna inquietud.</li></ul><p> <i>Tenga en cuenta que la experiencia de cada paciente puede variar y siempre debe seguir los consejos de su proveedor de atención médica.</i></p>"},"overview":{"text":"<h3>Inmunoterapia con Keytruda (pembolizumab)</h3> <p>Keytruda, una forma de terapia basada en la inmunidad, aprovecha el sistema inmunitario del organismo para atacar y destruir las células cancerosas mediante anticuerpos monoclonales.</p> <div>[<b>Ventajas:</b><span> Ofrece un enfoque dirigido con menos efectos secundarios; los ensayos clínicos muestran una tasa de respuesta del 70% en algunos tipos de cáncer. Adecuado para diversos tipos de cáncer gracias a sus propiedades de modulación inmunitaria.</span></div> <div>[icon-cons<b>]Contras</b><span>: Puede causar efectos adversos relacionados con el sistema inmunitario, como colitis o neumonitis, en hasta un 10% de los pacientes. Eficacia limitada en tumores con baja expresión de PD-L1.</span></div> <div>[icon-efecto<b>]Eficacia</b><span>: Tasa de respuesta del 70% en algunos tipos de cáncer.</span></div> <div>[icon-reloj<b>]Duración:</b><span> Cada sesión dura unos 30 minutos.</span></div> <div>[icon-run<b>]Recuperación:</b><span> No es necesaria.</span></div> <div>[icon-thumbs<b>]Lo mejor para:</b><span> Cánceres con alta expresión de PD-L1, melanoma y cáncer de pulmón no microcítico.</span></div> <div>[icon-price<b>]Precios:</b><span> [txt-país]</span></div>"}}},"relations":{"countries":[{"name":"Alemania","alias":"germany","iso_code":"DE"},{"name":"Azerbaiyán","alias":"azerbaijan","iso_code":"AZ"},{"name":"China","alias":"china","iso_code":"CN"},{"name":"Corea del Sur","alias":"republic-of-korea","iso_code":"KR"},{"name":"Egipto","alias":"egypt","iso_code":"EG"},{"name":"España","alias":"spain","iso_code":"ES"},{"name":"Estados 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Strenuous exercise within about a week, limited by fatigue."},"final_result_months":{"min":3,"max":6,"unit":"months","qualifier":"Best response often seen within 3-6 months; responses may deepen later."},"fly_home_after_days":{"min":1,"max":2,"unit":"days","qualifier":"Outpatient infusion with no wound; flying is possible once no reaction occurs and you feel well."},"follow_up_visits":[{"purpose":"assessment","requirement":"routine","after":{"min":21,"max":42,"unit":"days","qualifier":"Clinical review and blood tests before each subsequent cycle (every 3 or 6 weeks depending on regimen)."}},{"purpose":"result_review","requirement":"routine","after":{"min":42,"max":84,"unit":"days","qualifier":"First response imaging is typically about 6-12 weeks after starting treatment."}}],"indications":["Advanced or metastatic melanoma; adjuvant melanoma after resection","Non-small cell lung cancer (alone or with chemotherapy)","Head and neck squamous cell carcinoma","Classical Hodgkin lymphoma (relapsed/refractory)","Urothelial carcinoma","MSI-high/dMMR solid tumors including colorectal cancer","Other approved cancers (cervical, endometrial, gastric, renal, breast)","Merkel cell carcinoma"],"main_risks":["Immune-related organ inflammation (lungs, colon, liver, thyroid, kidneys, skin)","Fatigue, rash, itching, diarrhea, nausea","Infusion-related reactions","Type 1 diabetes, adrenal or pituitary insufficiency","Myocarditis (rare)","Serious or fatal immune events needing steroids and interruption"],"pain":"Minimal; only mild discomfort from IV cannulation. Side effects such as joint or muscle pain may occur in some patients.","preparation":["Confirmed cancer and approved indication; biomarker testing if relevant","Baseline blood tests: liver, kidney, thyroid, glucose","Baseline imaging for staging","Review of autoimmune history, transplant history and current medications","Pregnancy test and contraception counseling where relevant","Discussion of side effects and when to report symptoms urgently","Hepatitis B/C and HIV screening; exclude active tuberculosis","Baseline ECOG performance status assessment","Adequate venous access for intravenous infusion"],"recovery_timeline":[{"phase":"Infusion day","description":"About 30-minute IV infusion with brief observation; most patients go home the same day.","restrictions":[]},{"phase":"First days after each infusion","description":"Possible mild fatigue, rash or flu-like symptoms. Promptly report cough, breathlessness, severe diarrhea or rash, jaundice or weakness.","restrictions":[]},{"phase":"Ongoing treatment","description":"Cycles every 3 or 6 weeks with monitoring for delayed immune-related side effects, which can appear months into treatment or after it ends.","restrictions":["Do not self-treat immune-related symptoms; contact the oncology team"]}],"rehabilitation_days":{"min":0,"max":2,"unit":"days","qualifier":"Outpatient infusion with no surgical recovery; usual activities resume within 0-2 days, depending on fatigue and side effects."},"result_longevity":"In responders, benefit is often durable, lasting years and sometimes continuing after the course (up to about 2 years) ends. Duration depends on cancer type, stage and biomarkers.","revision_rate_pct":null,"scars":"No scarring is expected; at most there is a tiny, temporary mark at the IV cannulation site.","sessions_or_stages":{"sessions":{"min":1,"max":35,"unit":"visits","qualifier":"Infusions every 3 or 6 weeks for up to about 2 years (35 three-weekly cycles) or until progression."},"stages":[{"code":"infusion_cycles","label":"Repeated intravenous pembrolizumab infusions every 3 or 6 weeks","after":{"min":0,"max":730,"unit":"days","qualifier":"Spans the whole course from the first infusion."}}],"qualifier":"Number of cycles depends on cancer type, regimen, response and tolerance."},"success":{"metric":"Overall survival at 5 years (advanced NSCLC, PD-L1 ≥50%)","value":31.9,"unit":"percent","horizon":"5 years","population":"Adults with untreated advanced NSCLC, PD-L1 ≥50%, on pembrolizumab monotherapy","evidence_status":"limited"},"techniques":[{"name":"Pembrolizumab monotherapy","suits_whom":"Patients with suitable biomarkers (e.g., high PD-L1, MSI-high) or melanoma","recovery":"Outpatient infusion; no downtime in most patients."},{"name":"Pembrolizumab combined with chemotherapy","suits_whom":"Patients such as those with non-small cell lung cancer or other tumors where the combination is approved","recovery":"Added chemotherapy side effects can increase fatigue and recovery time after each cycle."}],"treatment_conditions":["outpatient"],"treatment_duration_hours":{"min":0.5,"max":1,"unit":"hours","qualifier":"Dose (200 mg every 3 weeks or 400 mg every 6 weeks) infused over 30 minutes, plus brief observation."},"initial_assessment_documents":["Pathology report with histology","PD-L1, MSI or dMMR test results","Staging CT or PET-CT reports","Prior treatment and surgery summary","Recent blood tests with liver and thyroid function","Oncologist letter on autoimmune disease or ECOG status"],"travel_trips":{"min":2,"max":35,"one_trip_possible":false,"qualifier":"Each 3- or 6-weekly infusion needs a visit; stay 1-3 days per trip. Fewer if a local oncologist continues."}}},"hrefLanguages":[{"rel":"alternate","hreflang":"ru","language":"ru","href":"https://ru.bookimed.com/clinics/country=dominikanskaya-respublika/procedure=kejtruda/"}],"offerFilters":{"offer_count":0,"country_filter":[{"id":34,"name":"España","alias":"spain","iso_code":"ES"}],"price_filter":{"from":0,"to":0,"avg":0}},"illnessesByOperation":[{"id":3,"alias":"breast-cancer","name":"Cáncer de mama"},{"id":4,"alias":"lung-cancer","name":"Cáncer de pulmón"},{"id":51,"alias":"stomach-cancer","name":"Cáncer de estómago"},{"id":53,"alias":"melanoma","name":"Melanoma"},{"id":100,"alias":"bladder-cancer","name":"Cáncer de vejiga"},{"id":125,"alias":"hodgkin-s-disease","name":"Linfoma de Hodgkin"},{"id":416,"alias":"rectal-cancer","name":"Cáncer de recto"},{"id":524,"alias":"colon-cancer","name":"Cáncer de colon"}],"rendersOffersList":false}