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Biography

Dr. Mehdi Afrit is a Medical Oncologist who practices at Burjeel Specialty Hospital in Sharjah. He has over 11 years of experience caring for and managing cancer patients. He has extensive experience providing chemotherapy, hormonal therapy, immunotherapy, and targeted therapy to patients. He earned a Certificate of Medical Oncology from the Gustave Roussy Institute in Paris, France, where he received training in antitumor chemotherapy and cancer medical treatment. Additionally, he holds an international certificate in breast diseases. He also has a certificate in Good Clinical Practice from Trans Celerate Biopharma Inc. and a certificate in Clinical Trial Management: Good Clinical Practice from the Faculty of Pharmaceutical Medicine of the Royal College of Physicians. He previously worked for over five years as an Assistant Professor of Medical Oncology at Tunis’s Faculty of Medicine. He later practiced as a Consultant, Medical Oncologist for six years at Arianna’s hospital in Tunisia. He later worked for two years as a Specialist Medical Oncologist at Zulekha Hospital. He was also an investigator in three international clinical trials and holds clinical trial auditing and CRO certifications and a GCP Training Certificate from 2016. He is a member in good standing of the Emirates Oncology Society (EOS), the European Society of Medical Oncology (ESMO), and the American Society of Clinical Oncology (ASCO). His clinical expertise includes but is not limited to the following:

• Oncology care and treatment for chemotherapy, hormonal therapy, immune therapy, and target therapy
• Breast cancer
• Solid tumor diagnosis
• Digestive cancer
• Gynecological cancer
• Lung cancer
• Genitourinary cancer
• Sarcoma

Awards & Achievements

• Award from Himaya Foundations and University of Sharjah

Research & Publications

• Clinicopathological Features of Gastric Cancer in a Cohort of Gulf Council Countries' Patients: A Cross-Sectional Study of 96 Cases. Journal of Oncology Research Reviews & Reports Volume 2(2): 1-3.
• The Burden of Gynecologic Cancers in the UAE. Journal of Oncology Research Reviews & Reports Volume 2(4): 1-6.
• The Emirates Oncology Task Force Clinical Practice Guideline on Screening for SARS-CoV-2 in Asymptomatic Adult Cancer Patients Before Anti-Cancer Therapy. Journal of Oncology Research Reviews & Reports Volume 2(4): 1-6.
• The State of Cancer Care in the United Arab Emirates in 2020: Challenges and Recommendations, A report by the United Arab Emirates Oncology Task Force. Humaid Al-Shamsi, Humaa Darr, Ibrahim Abu-Gheida , Jawaher Ansari, Martine, Mehdi Afrit, Mohamad H Masri, Mohamed Abuhaleeqa. Gulf J Oncology 2020 Jan;1(32):71-87.
• Primary Bone Lymphoma: Tunisian Multicentric Retrospective Study About 32 Cases. Ben Ayed C, Laabidi S, Said N, Afrit M, Ben Ahmed S, Boussen H. Tunis Med. 2018 May;96(5):269-272.
• First Site of Recurrence After Breast Cancer Adjuvant Treatment in the Era of Multimodality Therapy: Which Imaging for Which Patient During Follow-up? Nesrine M, Mehdi B, Houda EB, Soumaya L, Mehdi A, Bechir Z, Hamouda B. Breast Dis. 2017 Nov 21

Prof. Giorgio Walter Canonica is the Head of Personalized Medicine Center: Asthma and Allergy in Humanitas Research Hospital.

Medical areas of interest:
Asthma and allergies 

Research areas of interest: 
T cells: study of different subgroups and their functional role in basic and clinical research (allergy, specific autoimmunity of organs, degenerative diseases of the CNS and cancer).

Molecular events and interactions between immunocompetent cells, inflammatory cells, epithelial cells in allergic inflammation and airway remodelling.

Biomarkers that define the therapeutic response in asthma.

New antiallergenic drugs and new strategies in the treatment of allergic disease.

Clinical and immune-pharmacological activities of modifiers of biological responses such as cytokines, monoclonal antibodies, specific immunotherapy for allergens, etc.

Results of reported patients and assessment of quality of life in patients with respiratory and allergic diseases.

Prof. Canonica coordinated and conducted more than 50 tests (phase II-IV) according to current GCP rules (certification number 2426574, 29/06/2017).

He has also served as an arbitrator for most of the most important international journals - Editor-in-Chief of "Current Opinion in Allergy and Clinical Immunology" – Associated Editor "Annals of Allergy & Clinical Immunology".

Previous experience:
Director of the Degree programme of Lung Diseases at the University of Genoa (1998 - Today) President of the Clinic for Diseases of Allergies and Respiratory - Department of Internal Medicine, University of Genoa - IRCCS AOU San Martino IST

(1997) Director of the Specialized School of Allergy and Clinical Immunology DIMI, University of Genoa

• (1998-present) Full professor of allergies and respiratory diseases, Department of Internal Medicine, University of Genoa
   
• (1995-1998) Full professor of Internal Medicine, Department of Internal Medicine, University of Genoa
   
• (1982) Associate Professor Allergy and Clinical Immunology-Dept. of Internal Medicine
  (1977) Assistant Professor of Internal Medicine - University of Genoa
• (1973) Assistant at the Clinic of Pulmonary Diseases - University of Genoa

Publications:

https://www.ncbi.nlm.nih.gov/pubmed/?term=giorgio+walter+canonica

Prof. Luca Balzarini is the head of the Department of Diagnostic Imaging in Humanitas Research Hospital. He lectured at the post-graduation school in Radiology at the University of Milan and Pavia and he is member of the European Society of Radiology and of the Italian Society of Medical Radiology (SIRM).
He graduated cum laude in Medicine and Surgery at the University of Milan in 1982 and in 1986 he graduated cum laude at the post-graduation school of Radiology at the University of Milan.

His career started at Istituto Nazionale dei Tumori in Milano where he attended as a PHD student of the University of Milan.
After a long experience abroad, where he developed master expertise in Magnetic Resonance Imaging, he then became Assistant in the Department of Diagnostic radiology at Istituto Nazionale dei Tumori (IRCCS) in Milan where he has this role for 12 years now.

Since 1997 he has been working at Humanitas Research Hospital as head of Magnetic Resonance Section, and then head of Diagnostic Radiology Unit (2006). Nin 2012 he became head of Department of Diagnostic Imaging.

In his high technology Department there are 5 MRI machines (from 1 up to 3 T units), 4 CT scans, and an angiography suite, all radiological techniques are regulated by a system of dose control (Dose Watch).

His team, composed of 25 radiologists, has recognized expertise in several fields of Diagnostic and Interventional Imaging and particularly dedicated in Oncological, Muscle-Skeletal, Neuro and Cardiac Imaging.

Prof.  Marco Francone is the Cardiovascular Imaging Unit Director in Humanitas Research Hospital.

Medical areas of interest:

Imaging in cardiovascular and pulmonary diseases

Previous experience:

- First level Medical Director at the Department of Radiological, Oncological and Anatomy-Pathological Sciences, at Policlinico Umberto I in Rome

- Past-President, Cardiology Section at the Italian Society of Medical Radiology (SIRM)

Research areas of interest: 

Inflammatory heart disease, cardiomyopathy, imaging of acute myocardial infarction, imaging in cardio-toxicity, imaging of post-COVID patients.

Prof.  Marco Francone is the author of more than 150 indexed scientific papers with an impact factor of more than 500 and has lectured around the world for fifteen years, from the United States to Asia, from Africa to Australia.

Teaching experience:

Full Professor of Radio diagnostics at Humanitas University

Publications:

https://pubmed.ncbi.nlm.nih.gov/?term=marco+francone&sort=pubdate&size=200&show_snippets=off

Dr. Marco Grimaldi is the Diagnostic Neuroradiology Unit Director in Humanitas Research Hospital.

Medical areas of interest:

• magnetic resonance
• computed tomography
• angiography of the central nervous system, brain and spine
• study of the brachial plexus
• functional neuroradiology, in particular, study of cerebral perfusion for perfusion CT related to problems in an emergency regime
• spine dimorphism, in particular of the paediatric age and in rare diseases

He has developed full diagnostic, organizational and managerial autonomy of any problem in outpatient, hospital and emergency neuroradiology.

Research areas of interest:

• Functional imaging studies on coma
• Diagnosis and development of prognostic algorithms
• Research and development, even experimental, of new applications related to technological developments (research on new protocols for the use of the Multidetector Computed Tomography (MDCT), for the use of perfusion CT in vascular and emergency environments finally, study of the trachea in patients at risk of anesthesiology).

Previous experience:

1990 – 2012 Neuroradiologist at Hospital of San Gerardo in Monza, Italy

He was the Director on highly specialised activities related to functional neuroradiology. 

He worked in diagnostic autonomy, organization and management of any problem within neuroradiological outpatient, inpatient and emergency context. 

He is particularly interested in the field of functional neuroradiology, in research and experimental development of new applications also tied to technological developments and creation of new protocols for use of MDCT (use of CT perfusion imaging in the field of vascular and urgency. He was involved in the study of the trachea in patients at high anaesthetic risk), in paediatric radiology with particular reference to diagnosis and clinical management of rare diseases (consultant in the Outpatient Unit for metabolic diseases and in the Outpatient Unit for rare and genetic diseases at the Hospital). He is also interested in the study of problems related to the craniocervical junction.

Teaching experience: 

From 2002 to 2012 he has been a professor at Milano-Bicocca University of Milan.

From 2002 to 2012 : Professor of the courses "Technique and diagnostics for images I", "Technique and diagnostics for images II" and "Semeiotics neuroradiological CT" for the degree in Medical Radiology for Images and Radiotherapy.
From 2003 to 2012: Professor of the course "Functional Brain Diagnostics" for the Degree in Physiotherapy. 
From 2003 to 2012: Professor for the Degree Course in Neurotherapy and psychomotricity of the developmental age.
From 2006 to 2009: Lecturer at the School of Specialization in Radiodiagnostics.

Prof. Renato Maria Bragato is the Autonomous Echocardiography Unit Director in Humanitas Research Hospital.

His main medical specialties are 2D, 3D transthoracic and transesophageal echocardiographies.

He executes echo transthoracic and transoesophageal intra-operative monitoring in heart surgery, vascular surgery and hemodynamics (intra-operative diagnostics, cardiac function monitoring, mini-access treatment and surgery using the Heartport technique, monitoring implantation of vascular and valvular percutaneous endoprostheses, monitoring PFO closure, monitoring LAA Occluder and Mitral clip positioning), intraoperative evaluation and follow-up of application and correct functioning of “Ventricular Advanced Device” (VAD, NOVACOR, CIRCULATE),  resynchronisation and evaluation of bi-ventricular cardiac stimulation, vascular ultrasound (EchocolorDoppler of the supra-aortic trunks) and study of endothelial dysfunction (Shear test), evaluation of cardio-embolic risk using CEUS, transthoracic and transesophageal techniques.

Research areas of interest: His research activity is dedicated to Artificial Heart Device and Fusion Imaging.

Author and co-author of over 70 published papers on different national and international journals mainly from personal original research project

Member of Italian Society of Cardiovascular Echography (SIEC)

Publications: http://www.ncbi.nlm.nih.gov/pubmed/?term=bragato+renato

Dentist Hüdayi Boğahan has been serving at Dent X Clinics since 2017. 

He is a graduate of Şehremini High School. She started her undergraduate program in English at Marmara University Faculty of Dentistry in 2011. She took an active role in Marmara University Drama and Theater Club, Marmara University Latin Dance Club, Marmara University and Şehremini High School Debate Clubs. Our physician, who has also participated in domestic and international training and organizations in his professional career, is one of the founding partners of our clinics. 

He is a member of the Aesthetic Dentistry Academy Association (EDAD), Computar Aided Dentistry Academy (CADA), International Team of Implantology (ITI), and Istanbul Chamber of Dentists (IDO). 

He provides aesthetic dentistry services in our clinic and carries out digital design applications in our clinic with his thesis (2016) on digital smile design. Prosthetic dental treatments, leaf porcelains, implant-top coatings, zirconia and e-max applications are current working areas.

He continues to work in Dentx Küçükköy clinic and is the branch manager.

Expertise

E MAX, ZIRCONIA AND MONOLITHIC ZIRCONIA CROWNS

OVER IMPLANT PROTHESIS (ALL ON X)

LAMINATE VENEERS, DIGITAL SMILE DESIGN

OVERDENTURE PROTHESIS

DIGITAL PROSTHETIC DENTISTRY

DIGITAL WAXUP-MOCKUP APPLICATIONS

Memberships (in particular related to your Specialisation)

CADA (COMPUTER AIDED DENTISTRY ACADEMY)

EDAD (EASTHETİC DENTISTRY ACADEMY)

İDO (İSTANBUL CHAMBER OF DENTISTRY)

ITI (INTERNATIONAL TEAM OF IMPLANTOLOGY)

Any other educational courses and certificate (those conducted internationally as well):

1. Prosthetic Treatment Options in Implant Dentistry, 2019

2. Smile Design With Laminate Veneers, 2019 + 2020

3. Occlusion With All Type of Dentistry, 2019 + 2020 + 2021

4. Dental Photography Courses, 2018

5. Smile Designer Certificate - 2019

6. Practical Dental Photography Certificate - 2019

7. Digital Design and 3D Modelling Certificate - 2019

8. Nobel Biocare All on 4 Concept Immediate Total Rehabilitation – 2019

9. OSSTEM Prosthetic Treatment Options in Implant Dentistry – 2019

10. EDAD Digital Analog Smile Design Certificate – 2019

11. Dentsem Implant Complications on Surgery and Prosthetic Treatments – 2019

12. Aim Academy Contemporary Trends in Implantology – 2018

13. Implant Direct Occlusion Training – 2018

Treatment History

# of treatments conducted ALL TIME: OVER 20000

# of treatments conducted LAST CALENDAR YEAR (2021): 6000

Treatmen Success %97

Techniques used: DIGITAL WAXUP MODELLING TECHNIQUE

Equipment used: 3SHAPE INTRAORAL DIGITAL SCANNER

Prof. Antonio Costanzo is the Dermatology Unit Director in Humanitas Research Hospital. He graduated with his MD degree in Medicine and Surgery from the University of Rome, La Sapienza in 1994. He then went on to complete post-graduate study and received a speciality degree in Internal Medicine in 1999 and a Dermatology speciality degree in 2006.

Medical areas of interest:

• Inflammatory and autoimmune skin diseases (Psoriasis, Atopic Dermatitis, Alopecia Areata, Chronic Urticaria, Suppurative Hydroadenitis, Scleroderma, Lupus)
• Personalized Medicine, Biological Psoriasis Therapy
• Dermatological Oncology (Melanoma, Actinic Keratosis, Basocellular and Spinocellular Epitheliomas).
• Prevention of skin neoplasms (dermatoscopy, computer mapping of moles).
• Dermatological surgery

Previous experience:

• Director of Dermatology Unit at Sant’Andrea Hospital in Vercelli
• University Researcher/Hospital Assistant at Tor Vergata Hospital 

Research areas of interest: 

• Psoriasis pathogenesis of other inflammatory and autoimmune skin diseases
• Pathogenesis of skin neoplasms
• Genetic disorders of the skin

His clinical research is focused on the characterization of the activity of biologics in psoriasis and psoriatic arthritis. This research is strictly linked to basic research activity on the pathogenesis of psoriasis and on the use of pharmacogenetic approach to predict the efficacy and safety of biologics in psoriasis.

In the past, Professor Costanzo has collaborated to the characterization of basic mechanisms of TNF inflammatory signalling in epithelial cells and NFkappaB regulation by different stimuli. More recently his research group has collaborated to the discovery of IL-21 as critical mediator of keratinocyte proliferation in psoriasis. Professor Costanzo has authored or co-authored more than 120 publications in internationally peer-reviewed journals.

Teaching experience: Full Professor of Dermatology at Humanitas University

Publications: https://www.ncbi.nlm.nih.gov/pubmed/?term=Costanzo+A