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Prof. Filippini began his career in 1980 and has been teaching at the University of Chieti since the 1990s in the fields of General Surgery, Microsurgery, Reconstructive Surgery, Vascular Surgery, Orthopedics, and Gynecology. His primary focus is oncological surgery, particularly specializing in "The surgical treatment of locally advanced tumors and multi-organ resections." He has enriched his expertise by visiting prominent reference centers in the United States, including the Memorial Sloan Kettering Cancer Center in Manhattan, New York City. There, he delved into minimally invasive, laparoscopic, and microsurgical techniques under the guidance of esteemed mentors such as John Daly, Michele Gagner, and Murray Brennan. Additionally, in 2005, he further expanded his skills at the City of Hope Oncology Center in Los Angeles, focusing on robotic surgery in oncology.

In 1980, Prof. Filippini graduated in Medicine and Surgery from the G. D'Annunzio University of Chieti in Italy with honors, presenting an experimental thesis on lympho-venous anastomosis using microsurgical techniques. He completed his specialization in general surgery at the University of Pisa with distinction after five years. In 1990, he obtained another specialization in Plastic and Reconstructive Surgery from the University of Padua in Italy, where he maintained a stellar academic record.

Prof. Filippini has presented at numerous national and international conferences and authored over 100 scientific publications. Additionally, he has co-authored two monographs.