Tratamiento en Milán (Italia)

Professor Antonino Spinelli is the Director of the Division of Colon and Rectal Surgery at Humanitas Research Hospital.

The Division of Colon and Rectal Surgery is one of the most important centres for colorectal disease, especially for procedures of sphincter preservation for rectal tumours, but also for chronic inflammatory bowel disease (Crohn disease, ulcerative rectal colitis…) and the surgical treatment of diverticular pathologies. 

Professor Spinelli carries out a constant research on minimally invasive surgeries, including the single-port surgery, mini-laparoscopy, low-impact surgery and trans-anal techniques (TATME, TAMIS, TTSS). Furthermore, the advanced postoperative recovering is another area of his interest.

He graduated as MD in 2001 at University of Milano. During his education, he won several scholarships: he trained ad University of Berlin Charitè for two years at the Department of General, Visceral and Transplantation Surgery. Also, he obtained his PhD on Surgical Phsyiopathology with a dissertation on enhanced recovery for laparoscopic colorectal surgery in 2011. 

Current Teaching Activity: he is Full Professor of Surgery at Humanitas University. 

Also, Professor Spinelli is general Secretary of the European Society of Coloproctology (ESCP) and Board Member of the Guidelines Committee (GulCom) of the European Crohn Disease and Colitis Organization (ECCO). He is Fellow of the American Society of Colon and Rectal Surgery (FASCRS), Honorary Fellow of the Czech Society of Surgery (CSS) and Honorary Member of the Brazilian College of Digestive Surgery (CBCD). 

He is a member of the International Organization for the study of Inflammatory Bowel Disease (IOIBD) and several other national and international scientific societies. 

In addition, Professor Spinelli serves as Associate Editor for Colorectal Disease (Journal of the Association of Coloproctology of Great Britain & Ireland, Royal College of Surgeons of England, of the European Society of Coloproctology and of the Spanish Society of Coloproctology – Asociación Española de Coloproctología), Diseases of the Colon and Rectum (official journal of the American Society of Colon and Rectal Surgeons), Journal of the Anus, Rectum and Colon (official journal of the Japan Society of Coloproctology).

He is Editorial Board Member of the Journal of Crohn’s Colitis (official journal of the European Crohn’s Colitis Organization), Advisory Board of Coloproctology (official journal of the German Society for Coloproctology – Deutsche Gesellschaft für Koloproktologie) and Editorial Board Member of Updates in Surgery (official journal of the Italian Society of Surgery – Società Italiana di Chirurgia).

Professor Carlo Selmi is leading the Rheumatology and Clinical Immunology Unit at Humanitas Research Hospital. 

Since 2009, he is the responsible of the Autoimmunity and Metabolic Laboratory, dedicated to the study of the possible mechanism linked to the progression of autoimmune diseases. 

The research focuses on four main areas: 

• - The epigenetic mechanisms that regulate the environment-genomic interface by influencing the susceptibility and the phenotype of chronic autoimmune and inflammatory diseases in the model of discordant monozygotic twins for disease. To date, the laboratory has biological sample of discordant couples for numerous diseases.
• - The target antigens of autoimmunity modifications that affect the development of the course of autoimmune diseases. In particular, the laboratory studies the post-translational modifications of joint collagen in rheumatoid arthritis.
• - The prevalence of non-organ autoantibodies, such as anti-nucleus and anti-ENAs and disease specific autoantibodies, such as anti-citrulline and anti-endomysium in a non-specific population of health adults and the significance of the positive founds over time.
• - Gender medicine in real-life, through the analysis of administrative databases.

The team holds dedicated clinics also for, spondiloarthritis and connetcive tissue disease, and it is active in articular ultrasound, videocapillaroscopy, arthrocenthesis and joint injection of steroid or hyaluronic acid.  The Division includes an inpatient clinic for complex cases. All group members are fluent in spoken and written English

Current Teaching Activity: Professor Selmi works as Assistant Professor of Rheumatology at the University of Milan since 2006. Furthermore, he holds a joint appointment as Assistant Professor of Medicine at the Division of Rheumatology of the University of California at Davis since 2005.

He is member of the American College of Rheumatology, American Association of Allergists and Immunologists, and the Italian Society of Rheumatology. He serves on the International Group for Research on Psoriatic Disease (GRAPPA) and the working group for autoantibody standardization within the ACR (ASC).

Publications: Selmi C[Author] - Search Results - PubMed (nih.gov)

Dr. Paolo Omodei is the Unit Director of the Autonomous section of Clinical Gastroenterology.

He graduated with honors in the academic year 1988-89 at the Università degli studi of Milan. He specialized in Gastroenterology and Digestive Endoscopy in 1994. Winner of the competition for PhD in Research in Clinical Methodology in the academic year 1994-95. In 1996 he won the public competition for Assistant at the Gastroenterology Service of the Niguarda Ca' Granda Hospital in Milan. He held this post until June 1997. From 1997 to 1999 he held the position of Assistant at the Gastroenterology and Digestive Endoscopy Unit of Humanitas Clinical Institute, directed by prof. Alberto Malesci. From 2000 to 2006, he held the position of Assistant of the Gastroenterology and Digestive Endoscopy Unit of the Humanitas Clinical Institute. Since 2006 he has been Head of the Section of Emergency Gastroenterology and Head of Gastroenterology at the Humanitas Clinical Institute. He is Professor of Medicine and Surgery at the University of Milan.

1996-1997 Hospital of Niguarda, Milan, Italy
Assistant in the Gastroenterology and Digestive Endoscopy Services directed by Prof. Raffaele Arcidiacono

1987-1996 Polyclinic Hospital, Milan, Italy
Specialising in Gastroenterology in the Gastroenterology and Digestive Endoscopy service of the Institute of Internal Medicine directed by Prof. Nicola Dioguardi.
Volunteer medical specialist in the Gastroenterology and Digestive Endoscopy service in the Institute of Internal Medicine directed by Prof. Nicola Dioguardi.

Publications: http://www.ncbi.nlm.nih.gov/pubmed/?term=Omodei P

Prof. Romano Lutman is the Head Oncological and interventional radiology Unit.

Medical areas of interest: 
diagnostic and interventional oncology, in particular linked to percutaneous imaging-guided procedures.
He has performed over 3000 CT guided lung biopsies and numerous international trials on anticancer drugs.

Research areas of interest: 
advanced oncological diagnostics. Percutaneous minimally invasive imaging-guided diagnostic and therapeutic procedures in oncology.

Previous experience:  
- 1991-1996 Orthopaedic Institute of Gaetano Pini, Italy
Assistant Physiatrist
- 1991-1991 Hospital of the Piemonte region , Italy
Specialist doctor in sports medicine

Publications: http://www.ncbi.nlm.nih.gov/pubmed/?term=lutman r

Dr. Lorenzo Di Mento is the Head of the Traumatology Unit in Humanitas Research Hospital. He is also part of the council of AO Trauma Italy with the role of Community Development. 

He specialized in Orthopaedics and Traumatology at the University of Milan (2000-2005), completing several internships abroad:

• 2003 Marseille (France), Centre Phocea, Dr. Bronsard, vertebral surgery
• 2003 Marseille (France), Hopital Nord, Dr. Poitout, traumatology
• 2003-2004 Basse Terre (Guadeloupe), Centro Ospedaliero de la Basse Terre (CHBT), dr Fleurat, acting as intern (equivalent of the French specializing)

He also completed a Fellowship of AO Trauma International at the Centre Hospitalier Universitaire Vadois (CHUV) in Lausanne (Switzerland) in 2016, at the center of pelvic surgery and treatment of septic complications in orthopedics and traumatology, directed by Dr. Borens.

He surgically treats fractures, both acutely ongoing ones (with intervention of reduction and synthesis as soon as possible, in accordance with soft tissues and the patient’s conditions) and as psthumous traumas (pseudoarthrosis, bad or non consolidation). He handles polyfractured and polytrauma patients. Dr. Di Mento also treats infections in a traumatic environment, such as septic psedutoarthrosis and surgically the minor tumoral bone localizations, such as osteolysis, impending fractures and pathological fractures. 

Publications: https://pubmed.ncbi.nlm.nih.gov/?term=Di+Mento+L 

Prof. Guido Grappiolo is Orthopedics Hip and Prosthesis Unit Director in Humanitas Research Hospital. Since 1991, Prof. Guido Grappiolo began working as a researcher dedicated mainly to hip surgery in cooperation with internationally renowned authors such as: Prof. Ganz Prof. T. Gruen, Prof. D. Blaha (U.S.A.), Prof. H. Wagner (Germany), Prof. E. Morscher (Switzerland).

He collaborates with major international schools in the research of new and modern strategies in the field of minimally invasive prosthetics, computer-assisted surgery and conservative surgery. To encourage research in orthopedics is the main scientific goal of the establishment and organization of the "Foundation Livio Sciutto – NPO", an organization of which Prof. Grappiolo is the scientific director. Playing this role, Prof. Grappiolo has been creating and maintaining contacts with other national and international research institutes, which trained thousands of surgeons coming from every country of the world.

The organization has one of the largest hip replacement database of the world: more than 45.000. Dr. Grappiolo is mentored by Dr. Spotorno (a master and pioneer in prosthetic surgery), and their group studied and developed some of the bestselling prosthesis in the world. His research led him to contact the major international schools with which he collaborates in the search for new strategies of improvement in prosthetic minimally invasive and computer-assisted conservative surgery with the development of new prosthetic models and exploration of new materials.

To date, he has attended over 170 meetings, both national and international, almost every time in the role of speaker or chairman. His name appears as author, in more than 60 publications and articles. He has performed more than 2600 prosthetic surgery (hip, knee and ankle).

Publications: http://www.ncbi.nlm.nih.gov/pubmed/?term=grappiolo

Prof. Giorgio Walter Canonica is the Head of Personalized Medicine Center: Asthma and Allergy in Humanitas Research Hospital.

Medical areas of interest:
Asthma and allergies 

Research areas of interest: 
T cells: study of different subgroups and their functional role in basic and clinical research (allergy, specific autoimmunity of organs, degenerative diseases of the CNS and cancer).

Molecular events and interactions between immunocompetent cells, inflammatory cells, epithelial cells in allergic inflammation and airway remodelling.

Biomarkers that define the therapeutic response in asthma.

New antiallergenic drugs and new strategies in the treatment of allergic disease.

Clinical and immune-pharmacological activities of modifiers of biological responses such as cytokines, monoclonal antibodies, specific immunotherapy for allergens, etc.

Results of reported patients and assessment of quality of life in patients with respiratory and allergic diseases.

Prof. Canonica coordinated and conducted more than 50 tests (phase II-IV) according to current GCP rules (certification number 2426574, 29/06/2017).

He has also served as an arbitrator for most of the most important international journals - Editor-in-Chief of "Current Opinion in Allergy and Clinical Immunology" – Associated Editor "Annals of Allergy & Clinical Immunology".

Previous experience:
Director of the Degree programme of Lung Diseases at the University of Genoa (1998 - Today) President of the Clinic for Diseases of Allergies and Respiratory - Department of Internal Medicine, University of Genoa - IRCCS AOU San Martino IST

(1997) Director of the Specialized School of Allergy and Clinical Immunology DIMI, University of Genoa

• (1998-present) Full professor of allergies and respiratory diseases, Department of Internal Medicine, University of Genoa
   
• (1995-1998) Full professor of Internal Medicine, Department of Internal Medicine, University of Genoa
   
• (1982) Associate Professor Allergy and Clinical Immunology-Dept. of Internal Medicine
  (1977) Assistant Professor of Internal Medicine - University of Genoa
• (1973) Assistant at the Clinic of Pulmonary Diseases - University of Genoa

Publications:

https://www.ncbi.nlm.nih.gov/pubmed/?term=giorgio+walter+canonica

Prof. Alberto Albanese is the Neurology Unit Director at Humanitas Research Hospital. Until recently – Department Head of Neuroscience at the Institute of Neurology Carlo Besta (Milan). In 1977 prof. Albanese received his degree in medicine and surgery, in 1981 – in neurology, and in 1985 – in psychiatry. His professional experience began with the founding of the Department of “disorders of Parkinson’s and violations of the musculoskeletal system” at the clinic “A. Gemelli “in Rome in 1984, which he led until 1996. From 1996 to 2000 prof. Albanese was the Head of the Neurological University Clinic of Lausanne (Switzerland) and a professor of Neurology in the University.

From 2000 to 2015 he was Head of Neuroscience Department at the Institute of Neurology Carlo Besta (Milan).

Prof. Albanese is a professor of neurology at the Institute of Neurology at the Catholic University of the Sacred Heart (Milan), Director of the post-graduate course “Diagnosis and treatment of movement disorders and degenerative neurological diseases” at the Foundation Neurological Institute “C. Besta”, as well as an adjunct professor at the School of Specialization in Neuroscience at the University of Milan Bicocca.

Prof. Albanese is the president of “Italian Association of Parkinson’s disease and movement disorders” and “Italian Association for the Study of the autonomic nervous system” (which are part of “Italian Community of Neuroscience”). He is also an honorary member of the “French Community of Neuroscience.” The professor is a moderator and speaker at major national and international neurological conferences, he organized several symposia dedicated to Neurology, collaborates with numerous national and international research centers, which are studying Parkinson’s disease, movement disorders and degenerative neurological diseases. Prof. Albanese has been repeatedly receiving research fundings from the following government agencies: the Ministry of Health, Ministry of Science and Research, National Research Council, the British Council, the Swiss National Research Council.

He is one of the greatest Italian experts on the diagnosis and treatment of neurological diseases and movement disorders, Parkinson.

He has extensive experience in the use of neurostimulation of brain neurological movement disorders, for treating Parkinson’s disease and other involuntary movements.

He developed the first Italian project on the study of genetic disease and Parkinson’s dystonia, which led to the discovery of two new genetic loci. Also prof. Albanese is actively engaged in research in the field of semiotics detailed definition of involuntary movements, which allows tracking of related clinical pathology for accurate diagnosis of patients with movement disorders.

Prof. Albanese has published more than 200 scientific papers, most of which are published in indexed journals (with a total impact factor>500), is the author of one monograph, 3 books and co-author of numerous books and publications. He is the chief editor of “Frontiers in Movement Disorders” and assistant editor of the “European Journal of Neuroscience”.

Publications: http://www.ncbi.nlm.nih.gov/pubmed?term=albanese a

Prof. Alessandro Castagna is the Orthopedic Surgery of the Shoulder and Elbow Unit Director in Humanitas Research Hospital. He performs both traditional surgeries and arthroscopic surgeries. He developed experience in arthroscopic surgery of the shoulder in the United States where he studied at the Southern California Orthopedic Institute, under the guidance of Dr. Stephen J. Snyder (famous shoulder surgeon, inventor and co-developer of surgical tools for shoulder arthroscopy).

Prof. Castagna gained experience in open surgery of the shoulder under the guidance of Prof. Mario Randelli, founder and past-president of the Italian Society for Surgery of the Shoulder, in Milan (Italy). He has specialized almost exclusively in shoulder surgery for more than 25 years and counts over 40.000 cases in his career. He carries out about 900 surgeries per year, including total shoulder prostheses, reverse prostheses, open and arthroscopic stabilization, rotator cuff repair and proximal humerus fractures.

Research areas of interest: 

Improvement of surgical and therapeutic methods of shoulder pathology. He gives particular attention to the study of biological and functional aspects with the development of surgical techniques, materials and dedicated tools. 

Teaching experience: Adjunct Professor at the Orthopedics Course of Specialization in Diseases of the Locomotor System at the University of L'Aquila.

Scientific activity: 

Prof. Castagna was president of European Society for Surgery of the Shoulder and the Elbow (ESSSE/SECEC) (www.secec.org) from 2012 to 2014 and president of Italian Society for Surgery of the Shoulder and Elbow (SICS&G) (www.sicseg.it) from 2010 to 2012. He is also a Member of the Board di International Congress of Shoulder and Elbow Surgery (ICSES, www.icses.org) nominated for the period from 2013 to 2022.

Publications: http://www.ncbi.nlm.nih.gov/pubmed/?term=castagna+alessandro

Prof. Alessio Michele Goffredo Aghemo is the Hepatology Unit Director in Humanitas research Hospital.

Medical areas of interest: 

• liver diseases
• viral hepatitis
• metabolic hepatitis
• liver cirrhosis

Previous experience: 

From 2007 to 2017 he was the 1st level Medical Director at the U.O of Gastroenterology of the IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Milan.

Research areas of interest: 

Clinical and research activity focused on natural history and treatment of viral hepatitis.

He is the author of 155 peer-reviewed publications (Impact Factor total 1151.3, H-Index 25 according to Scopus, H-Index 20 last 5 years Scopus, H-Index 30 according to Google Scholar) (updated September 2017).

From 2013 to 2016 he was a scientific member of the governing board of the European Association for the Study of the Liver (EASL).

Since 2016 he is a member of the scientific committee of the European Association of Gastroenterology (UEG).

He is a member of the AISF (Italian Association for the Study of the Liver) commission for antiviral drugs directed against HCV (2012-present). Since 2016 he has been the coordinator of the same. 

He was AIFA/EMEA expert for liver disease since 2008.

Member of the Executive Committee of the HCV Regional Network, determined by the Lombardy Region on 28 September 2015.

He participated as an expert in the drafting of the European Guidelines 2013-2014-2015-2016-2017 (EASL) and Italian (AISF) on the Treatment of Chronic Hepatitis C.

Teaching experience:

He is associated professor of Gastroenterology at Humanitas University since September 2017.

Prof. Antonio Costanzo is the Dermatology Unit Director in Humanitas Research Hospital. He graduated with his MD degree in Medicine and Surgery from the University of Rome, La Sapienza in 1994. He then went on to complete post-graduate study and received a speciality degree in Internal Medicine in 1999 and a Dermatology speciality degree in 2006.

Medical areas of interest:

• Inflammatory and autoimmune skin diseases (Psoriasis, Atopic Dermatitis, Alopecia Areata, Chronic Urticaria, Suppurative Hydroadenitis, Scleroderma, Lupus)
• Personalized Medicine, Biological Psoriasis Therapy
• Dermatological Oncology (Melanoma, Actinic Keratosis, Basocellular and Spinocellular Epitheliomas).
• Prevention of skin neoplasms (dermatoscopy, computer mapping of moles).
• Dermatological surgery

Previous experience:

• Director of Dermatology Unit at Sant’Andrea Hospital in Vercelli
• University Researcher/Hospital Assistant at Tor Vergata Hospital 

Research areas of interest: 

• Psoriasis pathogenesis of other inflammatory and autoimmune skin diseases
• Pathogenesis of skin neoplasms
• Genetic disorders of the skin

His clinical research is focused on the characterization of the activity of biologics in psoriasis and psoriatic arthritis. This research is strictly linked to basic research activity on the pathogenesis of psoriasis and on the use of pharmacogenetic approach to predict the efficacy and safety of biologics in psoriasis.

In the past, Professor Costanzo has collaborated to the characterization of basic mechanisms of TNF inflammatory signalling in epithelial cells and NFkappaB regulation by different stimuli. More recently his research group has collaborated to the discovery of IL-21 as critical mediator of keratinocyte proliferation in psoriasis. Professor Costanzo has authored or co-authored more than 120 publications in internationally peer-reviewed journals.

Teaching experience: Full Professor of Dermatology at Humanitas University

Publications: https://www.ncbi.nlm.nih.gov/pubmed/?term=Costanzo+A 

Prof. Simona Marcheselli has graduated at the University of Pavia and carried out her specialisation in neuro-pathophysiology. She is the Emergency Neurology and Stroke Unit Director in Humanitas Research Hospital.

She is specialised in the treatment and prevention of cerebrovascular diseases. Her main specialties are Cerebral-vascular diseases, brain tumors, epilepsy, and headaches. Prof. Simona Marcheselli treats both ischemic and hemorrhagic stroke in the acute phase and its complications. Specific areas of interest are those related to secondary and primary prevention of cerebrovascular disease and post-stroke epilepsy.

She is also a professor at the nursing school of Humanitas University.

Publications: http://www.ncbi.nlm.nih.gov/pubmed/?term=marcheselli%s

Prof. Stefano Respizzi is the Head of the Rehabilitation and Functional Recovery Unit in Humanitas Research Hospital. He is specialized in orthopaedic rehabilitation and sport rehabilitation. In 1986, with some colleagues, he founded the Sports Medical Centre of Sesto San Giovanni. In 1988 he founded the GISMI (Italian Group of Study of Isokinetic Method), where he is also an advisor. 

Medical areas of interest: orthopaedic rehabilitation, traumatology and sports rehabilitation, sports medicine, physical therapy

Research areas of interest: orthopaedic rehabilitation, sports medicine, orthopaedics

Previous experience:  

• 1991-1996 Orthopaedic Institute of Gaetano Pini, Italy
  Assistant Physiatrist
• 1991-1991 Hospital of the Piemonte region , Italy
  Specialist doctor in sports medicine
   

In 1986, with some colleagues from Milan, he founded the Centro Medico Sportivo of Sesto San Giovanni, a facility recognized by Lombardia Region and dedicated to the release of certificates of fitness for practicing competitive sports.

He has been a consultant for the Italian Volleyball Federation.
In 1988 he founded GISMI (Gruppo Italiano Studio Metodiche Isokinetiche).
In 2002 he became managing director of Isokinetic Milano, one of the centers of the network of Isokinetic Sports Rehabilitation Centers.

Prof. Vittorio Quagliuolo is leading the team of Oncological Surgery and the Sarcoma Unit in Humanitas Cancer Center. His professional career started at the National Cancer Institute in Milan (under the guidance of prof. Umberto Veronesi) where he worked at the Department of Digestive & Hepatobiliary Surgery and Sarcoma Unit, chaired at that time by his mentor prof. Leandro Gennari, the pioneer of oncological hepatobiliary surgery in Italy, limb sparing surgery in sarcomas, sphincter saving surgery in colorectal cancer and liver transplantation for malgnancy.

Prof. Quagliuolo was one of the founding members of the European Society of Surgical Oncology (ESSO), of the European School of Oncology (ESO), European Society of Mastology (EUSOMA), and the Italian Sarcoma Group (ISG).

His surgical expertise is particularly founded on the field of soft tissue sarcomas of limbs and retroperitoneum with more than 1000 surgical resections. This activity is featured by the highest level of safety with an overall mortality close to 0%, and by the highest complexity of the patients, who often require a multidisciplinary approach, with the assistance of other experts in the operative theatre (vascular, plastic, orthopaedic, neuro and thoracic surgeons).

The Sarcoma Unit also cooperates with the most prestigious hospitals in Italy and in Europe participating in international clinical trials. The team has great skills in colorectal, endocrinological, upper GI, and peritoneum surgery.